Blar i NTNU Open på forfatter "Hyldbakk, Astrid"
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Alginate Microsphere Encapsulation of Drug-Loaded Nanoparticles: A Novel Strategy for Intraperitoneal Drug Delivery
Fleten, Karianne Giller; Hyldbakk, Astrid; Einen, Caroline; Benjakul, Sopisa; Strand, Berit Løkensgard; Davies, Catharina de Lange; Mørch, Ýrr Asbjørg; Flatmark, Kjersti (Peer reviewed; Journal article, 2022)Alginate hydrogels have been broadly investigated for use in medical applications due to their biocompatibility and the possibility to encapsulate cells, proteins, and drugs. In the treatment of peritoneal metastasis, rapid ... -
Cellular uptake and intracellular degradation of poly(alkyl cyanoacrylate) nanoparticles
Urdal, Jo Endre Brauten (Master thesis, 2020)Nanopartikler kan forbedre effekten og biodistribusjonen, og redusere toksisiteten til allerede eksisterende legemidler ved å innkapsle dem. I tillegg, nanopartikler kan legge til rett for leveringen av legemidler som er ... -
A comparative biodistribution study of polymeric and lipid-based nanoparticles
Åslund, Andreas; Vandebriel, Rob J.; Caputo, Fanny; de Jong, Wim H.; Delmaar, Christiaan; Hyldbakk, Astrid; Rustique, Emilie; Schmid, Ruth Baumberger; Snipstad, Sofie; Texier, Isabelle; Vernstad, Kai; Borgos, Sven Even F. (Peer reviewed; Journal article, 2022)Biodistribution of nanoencapsulated bioactive compounds is primarily determined by the size, shape, chemical composition and surface properties of the encapsulating nanoparticle, and, thus, less dependent on the physicochemical ... -
Corrosion and degradation in MEA based post-combustion CO2 capture
Fytianos, Georgios; Ucar, Seniz; Grimstvedt, Andreas Magnar; Hyldbakk, Astrid; Svendsen, Hallvard Fjøsne; Knuutila, Hanna K. (Journal article; Peer reviewed, 2016)Two of the main challenges in post-combustion CO2 capture with ethanolamine are solvent degradation and material corrosion. It has been shown that there is a correlation between degradation and corrosion. The present paper ... -
Identification of novel cyanoacrylate monomers for use in nanoparticle drug delivery systems prepared by miniemulsion polymerisation – A multistep screening approach
Hyldbakk, Astrid; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Åslund, Andreas; Klinkenberg, Geir; Nakstad, Vu; Wågbø, Ane Marit; Schmid, Ruth Baumberger; Molesworth, Peter Patrick (Peer reviewed; Journal article, 2022)Poly (alkyl cyanoacrylate) (PACA) polymeric nanoparticles (NPs) are promising drug carriers in drug delivery. However, the selection of commercially available alkyl cyanoacrylate (ACA) monomers is limited, because most ... -
Intraperitoneal administration of cabazitaxel-loaded nanoparticles in peritoneal metastasis models
Hyldbakk, Astrid; Fleten, Karianne Giller; Snipstad, Sofie; Åslund, Andreas; Davies, Catharina de Lange; Flatmark, Kjersti; Mørch, Ýrr Asbjørg (Peer reviewed; Journal article, 2023)Colorectal and ovarian cancers frequently develop peritoneal metastases with few treatment options. Intraperitoneal chemotherapy has shown promising therapeutic effects, but is limited by rapid drug clearance and systemic ... -
Nanostructured lipid carriers for controlled and triggered drug delivery : synthesis and advanced characterisation
Hyldbakk, Astrid (Master thesis, 2016)The emerging field of nanomedicine allows development of targeted drug delivery systems that improves the efficiency and bioavailability of important therapeutics in the clinic. Translation of engineered nanoparticles for ... -
Polyethylene glycol (PEG) as a broad applicability marker for LC–MS/MS-based biodistribution analysis of nanomedicines
Hyldbakk, Astrid; Hansen, Terkel; Hak, Sjoerd; Borgos, Sven Even F. (Journal article; Peer reviewed, 2024)Polyethylene glycol (PEG) conjugation (PEGylation) is a well-established strategy to improve the pharmacokinetic and biocompatibility properties of a wide variety of nanomedicines and therapeutic peptides and proteins. ... -
Polymeric nanoparticles for intraperitoneal cancer treatment: Development and characterisation of a novel drug delivery platform
Hyldbakk, Astrid (Doctoral theses at NTNU;2023:97, Doctoral thesis, 2023)The emerging field of nanomedicine allows development of drug delivery systems that improve the efficiency and bioavailability of therapeutics. Poly(alkyl cyanoacrylate) (PACA) nanoparticles have been widely studied as ... -
Ultrasound-Mediated Delivery of Chemotherapy into the Transgenic Adenocarcinoma of the Mouse Prostate Model
Fagerland, Stein-Martin Tilrum; Berg, Sigrid; Hill, Deborah Katherine; Snipstad, Sofie; Sulheim, Einar; Hyldbakk, Astrid; Kim, Jana; Davies, Catharina de Lange (Peer reviewed; Journal article, 2020)Ultrasound (US) in combination with microbubbles (MB) has had promising results in improving delivery of chemotherapeutic agents. However, most studies are done in immunodeficient mice with xenografted tumors. We used two ...